TIE2 (TEK) (Y897S Mutant) Proteins

TIE2 (TEK) (Y897S Mutant) Human recombinant proteins are validated for use in the following applications: Kinase Assay. Available Product Grades: RUO. Browse 1 protein. Not finding the exact protein, grade or size needed?... TIE2 (TEK) (Y897S Mutant) Human recombinant proteins are validated for use in the following applications: Kinase Assay. Available Product Grades: RUO. Browse 1 protein. Not finding the exact protein, grade or size needed? Contact us... TIE2 (TEK) (Y897S Mutant) Human recombinant proteins are validated for use in the following applications: Kinase Assay. Available Product Grades: RUO. Browse 1 protein. Not finding the exact protein, grade or size needed? Contact us to discuss your specific application and product needs.... TIE2 (TEK) (Y897S Mutant) Human recombinant proteins are validated for use in the following applications: Kinase Assay. Available Product Grades: RUO. Browse 1 protein. Not finding the exact protein, grade or size needed? Contact us to discuss your specific application and product needs.

Protein Information

TEK (TIE2) Y897S receptor tyrosine kinase is expressed principally on vascular endothelium. Disrupting TEK Y897S function in mice results in embryonic lethality with defects in embryonic vasculature, suggesting a role in blood vessel maturation and maintenance. Angiopoietin-1 is a secreted growth factor that binds to and activates the TEK receptor tyrosine kinase. SHP2 and GRB2 are recruited to the activated TEK kinase domain and are part of the cellular responses that mediate TEK function. TEK expression is upregulated in the endothelium of vascular 'hot spots' in human breast cancer specimens. However, TEK is also overexpressed in areas of active angiogenesis in normal tissues.

Synonyms

TIE2

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Invitrogen

Human TEK (TIE2) [Y897S], GST Tag Recombinant Protein

Invitrogen

Human TEK (TIE2) [Y897S], GST Tag Recombinant Protein

Species

Human

Expression System

Insect cells

Product Grade

Research Use Only

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Cat # A30519

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TIE2 (TEK) (Y897S Mutant) Proteins

Protein Information

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